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For biomedical applications, NPs with biocompatible shells, e.g., coated by inert inorganic materials (such as SiO Cubic shape is important due to the change in the magnetic properties and lower saturation magnetization could expand the application to T1 or a dual mode contrast agent. Herein, we apply this reduction method on cubic with an unusual cubic core morphology and furthermore characterize their magnetic and relaxation properties on a clinical 3.0 T MRI instrument. coated Fe nanoparticles increased with decreasing SiO Furthermore, saturation magnetization of the spherical SiO They later demonstrated this reduction method to be applicable for synthesis from spherical. Fe NPs and lowered the reduction working temperature down to 20–300Ĭ. used CaHĪs a reducing agent for the synthesis of spherical Fe NPs is carried out via reduction of spherical SiO Traditionally, in solid state, the preparation method for spherical SiO Fe NPs and their MRI relaxivity measurements. Herein, we focus on solid state synthesis of Additionally, iron NPs with TRITC–dextran coating (size <20 nm) were synthesized using cryomill and with saturation magnetization (180 per g-Fe). Another study on PEGylated showed that they are a promising MRI contrast agent. Fe NPs with cPEG coating was performed by the optimized chemical reduction of ferrous chloride with sodium borohydride. The latter argument has prompted this study, where we synthesize and investigate NPs with a metallic cubic iron core. Fe NPs have potential to produce better quality images for high-performance MRI. Increase the relaxation rate of proton spins according to 1/T Values are crucial for MRI signal enhancement since contrast agents with high Fe) saturation magnetization of 218 emu per g-Fe exceeds these numbers nearly twofold. Values of 124 emu per g-Fe and 109 emu per g-Fe, respectively. Typically, investigated SPIONs, magnetite (Fe One downside of SPIONs is that their saturation magnetization ( The review is completed with conclusion and a brief perspective on future development of core–shell particles in chromatography.Is the relaxation rate in the absence of magnetic NPs. The use of columns packed with core–shell particles in different types of liquid chromatography is then discussed, followed by illustrating example applications of such columns for separation of various types of samples. The core–shell particles are compared with totally porous silica particles and also monolithic columns. The fundamentals are discussed on why core–shell particles can perform better with low back pressure, in terms of van Deemter equation and kinetic plots. In this review, we firstly show the types of core–shell particles and how they are generally prepared, focusing on the methods used to produce core–shell silica particles for chromatographic applications. In recent years, core–shell silica microspheres (with a solid core and a porous shell, also known as fused-core or superficially porous microspheres) have been widely investigated and used for highly efficient and fast separation with reasonably low pressure for separation of small molecules, large molecules and complex samples. Fast separation often results in very high operating pressure, which places a huge burden on HPLC instrumentation. The challenges in HPLC are fast and efficient separation for a wide range of samples.